The pancreas develops from the endodermal lining of the caudal part of the foregut that forms the duodenum. Two buds pouch from the endoderm; a larger bud, the dorsal pancreatic bud appears first in the dorsal mesentery followed by a smaller bud, the ventral pancreatic bud that appears in close relation with the bile duct. The duct system and parenchyma develop in each bud then fuse to form one organ. This results in the formation of the principal pancreatic duct of Wirsung. The proximal part of the dorsal pancreatic bud may become atretic and obliterated or persist as the accessory pancreatic duct of Santorini drains into the duodenum through the minor papilla. About 10% fail to fuse leading to two drainage systems each draining to the closest portion of the gut.
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