The authors argue that this method is preferable since it can be used in current sequencing techniques which are dependent on nanopore technology. With that in mind, Soni et al (p 1) illustrate this possibility by probing double-stranded DNA as well as DNA-protein complexes using optic means while passing through a pore of approximately 4 nanometers. It is suggestive that this experiment showed that when electric force accts on protein-DNA complex, it at the nanoscale pore results into the duplex DNA unzipping. It is for this reason that the method is possibly applicable in the DNA sequencing methods that are composed of single molecules and these are viewed as belonging to the â€œnext-generationâ€.
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